5-MeO-DMT is a tryptamine-based psychedelic which is legal in Canada. While this compound has been found in one toad species and numerous plants, it was first synthesized in 1936 by two Japanese chemists, and is only now becoming known in the psychedelic space. It is important to note that while 5-MeO-DMT is related to dimethyltryptamine (DMT), they are two very different compounds. 5-MeO-DMT is considerably more potent and produces a much different experience of ego dissolution into non-dual unity consciousness. Learn more at F.I.V.E.
While 5-MeO-DMT is a relatively new psychedelic, having only entered underground circles in the 90s, there has been some scientific study that illustrates why it is commonly referred to as the world’s most powerful psychedelic.
A peer reviewed meta-study of 5-MeO-DMT in the Journal of Neurochemistry found that: “
Observational studies and surveys have suggested that single exposure to 5-MeO-DMT can cause rapid and sustained reductions in symptoms of depression, anxiety, and stress.”
A published review of all Pub-Med research on 5-MeO-DMT concluded:
“5-MeO-DMT is a short-lasting psychedelic substance with a unique subjective effect profile. A notable feature of 5-MeO-DMT is the reportedly high rates of the ego-dissolution and mystical experiences, which in studies with other psychedelics are related to long-term positive therapeutic outcomes.”
Alan K Davis and team surveyed people who had utilized 5-MeO in group settings with preparation, guidance, and integration support. Of participants who had been diagnosed with depression, 80% reported an improvement in their symptoms, and 79% of those diagnosed with anxiety observed improvements.
This is consistent with 2019 research of 42 participants that found a single inhalation of 5-MeO-DMT increased life satisfaction and mindfulness, decreased anxiety, stress, and depression, and that these changes were sustained four weeks after the experience.
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